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Drug Target Identification and Chemical Proteomics
• LeadArt Technologies provides closed-loop services from active compounds to target identification
• Probe synthesis and target identification are customized service items of chemical proteomics
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Peptidomics
Peptide group refers to all endogenous polypeptides in biological tissues or body fluids, including signal molecules (such as cytokines, growth factors, and hormones), antibacterial peptides, and immune peptides. These small peptides have been confirmed by more and more studies to have important biological significance. Peptidomics is a discipline that studies the structure, function, change rules and related relationships of peptide groups. Peptidomics is a supplement to proteomics. Peptomics can search for peptide markers with biological significance and screen potential therapeutic drugs with biological activity.
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Conventional Proteomics
The concept of proteome was first proposed by Australian scholars in 1995. It is derived from the hybridization of the two words protein and genome, which refers to a specific time and space. Genome, all the proteins expressed by a cell tissue or an organism. The study of proteomics is called proteomics, which is mainly to study the composition and activity of proteins in cells at the overall level. The specific research content of proteomics includes: protein qualitative and quantitative analysis, protein post-translational modification research, protein structure research, protein function research, small molecule-protein and protein-protein interaction research, etc. Quantitative analysis is divided into non-labeled quantification (label free) and labeled quantification (SILAC, iTraq, TMT, etc.).
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Phenols Active Compounds Library Probe+ -
Polyphenol Active Compounds Library Probe+ -
Flavonoid Active Compounds Library Probe+ -
Jujube Active Compounds Library Probe+ -
Salicylic Acid Active Compounds Library Probe+ -
Anti-Cancer Active Compounds Library Probe+ -
Immunologically Active Compounds Library Probe+ -
Anti-Aging Active Compounds Library Probe+ -
Case Study
| Product Name | Cat. No. | Compounds | Size (10 mM in Pre-dissolved in DMSO ) |
| Phenols Active Compounds Library Probe+ | LA-001 | Active Compounds 265 M Series 472 C Series 623 |
96-well plates 10 μL/well, 20 μL/well, or 100 μL/well |
Phenolic compounds mainly refer to a class of hydroxyl (-OH) or methoxy (-OMe) directly combined with aromatic base groups, which have strong antioxidant properties, antibacterial and enzyme properties, anti-tumor and other functions Natural products.
| Product Name | Cat. No. | Compounds | Size (10 mM in Pre-dissolved in DMSO ) |
| Polyphenol Active Compounds Library Probe+ | LA-002 | Active Compounds 198 M Series 427 C Series 522 |
96-well plates 10 μL/well, 20 μL/well, or 100 μL/well |
Polyphenol compounds mainly refer to a class of natural products composed of two or more hydroxyl groups (-OH) or methoxy groups (-OMe) directly combined with aromatic hydrocarbon groups. They are widely found in plants and have strong antioxidant properties. Antibacterial and enzyme-inhibiting properties, anti-tumor and other multifunctional natural products. The main structure includes flavonoids, quinones, alkaloids, phenylpropanoids and other polyphenols.
| Product Name | Cat. No. | Compounds | Size (10 mM in Pre-dissolved in DMSO ) |
| Flavonoid Active Compounds Library Probe+ | LA-003 | Active Compounds 52 M Series 163 C Series 165 |
96-well plates 10 μL/well, 20 μL/well, or 100 μL/well |
Flavonoids are widely found in plants in nature and belong to the secondary metabolites of plants. Flavonoids are a type of yellow pigment derived from flavonoids (2-phenylchromone) as the core. Flavonoids are widely present in plants and are natural products with strong antioxidant properties, antibacterial and enzyme properties, anti-tumor and other multi-functional natural products.
| Product Name | Cat. No. | Compounds | Size (10 mM in Pre-dissolved in DMSO ) |
| Jujube Active Compounds Library Probe+ | LA-004 | Active Compounds 27 M Series 76 C Series 113 |
96-well plates 10 μL/well, 20 μL/well, or 100 μL/well |
Zizyphus jujuba dates (zizyphus jujuba dates) are the fruits of the jujube tree (zizyphus iujuba Mill) of the genus Rhamnaceae. Modern pharmacology has found that red dates contain a variety of active natural products, such as carbohydrates, vitamins, triterpenoids, cyclic adenosine phosphate and polyphenols.
| Product Name | Cat. No. | Compounds | Size (10 mM in Pre-dissolved in DMSO ) |
| Salicylic Acid Active Compounds Library Probe+ | LA-005 | Active Compounds 17 M Series 25 C Series 48 |
96-well plates 10 μL/well, 20 μL/well, or 100 μL/well |
Salicylates (Salicylates) drugs include aspirin and sodium salicylate (Sodium Salicylate), etc., due to its strong irritation, salicylic acid itself is only used as an antifungal and keratolytic agent.
| Product Name | Cat. No. | Compounds | Size (10 mM in Pre-dissolved in DMSO ) |
| Anti-Cancer Active Compounds Library Probe+ |
LA-006 | Active Compounds 139 M Series 201 C Series 295 |
96-well plates 10 μL/well, 20 μL/well, or 100 μL/well |
In currently, Cancer one of the most common and most serious diseases that directly endanger human life. According to incomplete statistics, nearly 20 million people in the world suffer from cancer every year, and about 10 million people die from cancer, accounting for the total number of deaths. About 1/4, this number is still growing rapidly.
| Product Name | Cat. No. | Compounds | Size (10 mM in Pre-dissolved in DMSO ) |
| Immunologically Active Compounds Library Probe+ | LA-008 | Active Compounds 75 M series 131 C series 167 |
96-well plates 10 μL/well, 20 μL/well, or 100 μL/well |
"Immunity" is an extremely important self-defense function of the human body. The human body can resist a huge variety of diseases by relying on its own immunity. Many active substances in natural products have immunological activity, such as polyphenols, flavonoids, and nitrogen-containing heterocyclic compounds.
| Product Name | Cat. No. | Compounds | Size (10 mM in Pre-dissolved in DMSO ) |
| Anti-Aging Active Compounds Library Probe+ | LA-009 | Active Compounds 118 M Series 230 C Series 274 |
96-well plates 10 μL/well, 20 μL/well, or 100 μL/well |
Baicalin is an active ingredient in a class of natural products. It has been found to reduce the accumulation of lipids in cells. In order to study its corresponding protein targets and biological activity mechanisms, the researchers designed probe molecules corresponding to its active ingredients and carried out chemistry. The identification of proteomics found that the protein target corresponding to baicalin was CPT1A, and through subsequent binding experiments, in vitro activity experiments, and animal phenotyping experiments, the mechanism of its CPT1A target was verified, and it was successful. The anti-obesity and anti-steatosis effects of baicalin depend on its interaction with CPT1A.
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Nature里程碑：糖尿病治疗新靶点——胰岛素抑制受体
2021年01月30日
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Cell报道丨西湖大学郭天南等首次揭示新冠患者蛋白质分子病理全景图
2021年01月09日
