Flavonoid Active Compounds LibraryTarget Probe+
Flavonoid Active Compounds Library Target Probe+
Product Name Cat. No. Compounds Size (10 mM in Pre-dissolved in DMSO )
Flavonoid Active Compounds Library Target Probe+ LA-003 Active Compounds 52 
M Series 163
C Series  165
96-well plates
10 μL/well, 20 μL/well,  or 100 μL/well


  Flavonoids are widely found in plants in nature and belong to the secondary metabolites of plants. Flavonoids are a type of yellow pigment derived from flavonoids (2-phenylchromone) as the core. Flavonoids are widely present in plants and are natural products with strong antioxidant properties, antibacterial and enzyme properties, anti-tumor and other multi-functional natural products. 
  The library currently contains 52 flavonoids, and its M+C series derivatives have reached ~330 and continue to increase rapidly. It provides a variety of flavonoids as the core and the library for drug screening. It continues to increase, providing new and diversified screening tools for drug screening. Table 1 shows some of the natural products of flavonoids and the sites of post-modification probe molecules.

 

 

图 1 黄酮类活性化合物已知相关疾病领域

 

 

表2 黄酮类活性化合物药物靶点示例

Cytochrome P450 1A2/1B1/1A1 (by homology) Xanthine dehydrogenase/oxidase Aldehyde oxidase (by homology) Microtubule-associated protein tau
Aldose reductase Aldo-keto reductase family 1 member B15/B10 (by homology) NADPH oxidase 4 Alcohol dehydrogenase [NADP(+)] (by homology)
1,5-anhydro-D-fructose reductase (by homology) Multidrug resistance-associated protein 1 Canalicular multispecific organic anion transporter 1/2 (by homology) Sodium/glucose cotransporter 1/2
Low affinity sodium-glucose cotransporter ATP-binding cassette sub-family G member 2 Carbonyl reductase [NADPH] 1/3 Plasmin light chain B
Apolipoprotein(a) (by homology) Estradiol 17-beta-dehydrogenase 1 Retinol dehydrogenase 8 (by homology) Tyrosyl-DNA phosphodiesterase 1
[flavin-containing] A/B (by homology) Beta amyloid A4 protein Adenosine receptor A3/A1 Cyclin-dependent kinase 1/2/3/4/6
Muscleblind-like protein 1/2 Dual specificity tyrosine-phosphorylation-regulated kinase 1A (by homology) Alpha-2A adrenergic receptor Prostaglandin G/H synthase 1/2 (by homology)
Nitric oxide synthase Aldehyde dehydrogenase Cytosolic 10-formyltetrahydrofolate dehydrogenase (by homology) Mitochondrial 10-formyltetrahydrofolate dehydrogenase (by homology)
3-oxo-5-alpha-steroid 4-dehydrogenase 1 cGMP-specific 3',5'-cyclic phosphodiesterase Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (by homology) Epidermal growth factor receptor
Receptor tyrosine-protein kinase erbB-2 (by homology) ERBB4 intracellular domain (by homology) Carbonic anhydrase Beta-secretase 1/2
3-phosphoinositide-dependent protein kinase 1 Cyclic AMP-responsive element-binding protein 1 FAD-linked sulfhydryl oxidase ALR Arachidonate 12-lipoxygenase, 12S-type (by homology)
 
Induced myeloid leukemia cell differentiation protein Mcl-1 22 kDa interstitial collagenase Stromelysin-1/-2 Macrophage metalloelastase
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