Jujube Active Compounds Library Probe+
Jujube Active Compounds Library Probe+
Product Name Cat. No. Compounds Size (10 mM in Pre-dissolved in DMSO )
Jujube Active Compounds Library Probe+ LA-004 Active Compounds 27
M Series 76
C Series  113
96-well plates
10 μL/well, 20 μL/well,  or 100 μL/well

 

  Zizyphus jujuba dates (zizyphus jujuba dates) are the fruits of the jujube tree (zizyphus iujuba Mill) of the genus Rhamnaceae. Modern pharmacology has found that red dates contain a variety of active natural products, such as carbohydrates, vitamins, triterpenoids, cyclic adenosine phosphate and polyphenols. Among the polyphenolic compounds are rutin, quercetin, apigenin, puerarin, kaempferol, gallic acid, protocatechuic acid, p-hydroxybenzoic acid, caffeic acid, p-coumaric acid, chlorogenic acid, ferulic acid , Cinnamic acid, catechin, epicatechin, vanillic acid, etc. [1-5]. They are widely used in the research of kinases [6,7], anti-cancer [8-12], infections [13-15], metabolic diseases [16-18], inflammation/immunity [10,19, 20] and other fields . Its safety and effectiveness have been confirmed by literature, patent reports and clinical research.      
   LeadArt Technologies Jujube series library has collected 27 known polyphenolic jujube active molecules and modified 189 M+C series derivatives (probe compounds) on them. It is a scientific community and academy interested in jujube. Provide a more competitive and comprehensive drug screening model.

References:

[1]  J. Agric. Food Chem., 2011, 59(4), 1288–1292. [2] Chromatographia, 2010,71(7-8), 703–707. [3]  Asia-Pacific Traditional Medicine, 2020, 16, 202-205. [4] J. Food Comps Anal2010, 23(7), 706-710. [5] Food Chem, 2009, 112, 858-862. [6] J Med Chem. 2006, 49(8), 2363-6. [7] Toxicol Appl pharm, 2013, 269(2), 89-99. [8] Exp Anim. 2015, 64(2), 161-9. [9] World J Gastroenterol. 2013, 21;19(43), 7726-34. [10] Biomed Chromatogr. 2011, 25(7), 783-93. [11] Cell Oncol (Dordr). 2015, 38, 111-118. [12] Int. J. Mol. Sci. 2019, 20, 2149. [13] Biosci Biotechnol Biochem. 1998, 62(11), 2273-6. [14] Environ Toxicol, 2018, 33(4), 436-445. [15] Sci Rep. 2017, 18(7), 40753. [16] Am J Vet Res, 2011, 72(12), 1569-1575. [17] Int J Biol Sci, 2019, 15(11), 2497-2508. [18]  Int J Antimicrob Ag. 2019, 54(1), 80-84. [19] J Nutr Biochem, 2015, 26(11), 1379-84. [20] Int J Biol Macromol. 2016, 25(89), 175-180.

Figure 1 The Compound Screenings of red jujube related diseases

 


Table 2 Examples of known drug targets

Sodium/glucose cotransporter 1/2 Low affinity sodium-glucose cotransporter  Solute carrier family 28 member 3 Carbonic anhydrase II/I/III/VI/XII/XIV IX/VA
Alpha-(1,3)-fucosyltransferase 7 Squalene monooxygenase (by homology) ATP-binding cassette sub-family G member 2 Aldose reductase (by homology)
Cytochrome P450 1B1 Xanthine dehydrogenase NADPH oxidase 4 Plasminogen
MORE