Anti-Cancer Active Compounds Library Probe+
Anti-Cancer Active Compounds Library Probe+
Product Name Cat. No. Compounds Size (10 mM in Pre-dissolved in DMSO )
Anti-Cancer Active Compounds 
Library Probe+
LA-006 Active Compounds 159
M Series 296
C Series  371
96-well plates
10 μL/well, 20 μL/well,  or 100 μL/well


   In currently, Cancer one of the most common and most serious diseases that directly endanger human life. According to incomplete statistics, nearly 20 million people in the world suffer from cancer every year, and about 10 million people die from cancer, accounting for the total number of deaths. About 1/4, this number is still growing rapidly.       
  Cancer is a chronic disease that the world medical community has been unable to overcome for a long time. One of the reasons is that the modern medical community has not really understood the cause of cancer. To this end, the library contains 159 anti-cancer active molecules, and the M+C series are transformed into potential new active molecules on each parent (~660), which can be widely used in high-throughput screening (HTS). ) And high-content screening (HCS), providing important clues for optimizing drug structure; at the same time, we continue to provide customized P-series molecules (~117 modified), which can be used for precise protein profiling research and discovery of drugs in various cells , Including the binding of human living cells to various protein targets, for in-depth research on the mechanism of drug action and drug modification.


Figure 1 Research Area of Anti-cancer Compounds

 

 

 

 

Table 2 Examples of known drug targets for anticancer Compounds

 

Microtubule-associated protein tau Carbonic anhydrase II/VII/XII/IV Tyrosyl-DNA phosphodiesterase 1  Estrogen receptor alpha
Xanthine dehydrogenase Arachidonate 15-lipoxygenase B/ Arachidonate 5-lipoxygenase Adenosine receptor A1/A3 (by homology) Cytochrome P450 1B1/1A2/1A1/19A1
Aldo-keto reductase family 1 member B10 (by homology) Androgen receptor  P-glycoprotein 1 ATP-binding cassette sub-family G member 2
Epidermis-type lipoxygenase 3 (by homology) Aldehyde dehydrogenase Vascular endothelial growth factor receptor 1/2/3 (by homology) Muscleblind-like protein 1/2/3
5-hydroxytryptamine receptor 2A/2B/2C (by homology) Beta amyloid A4 protein Platelet-derived growth factor receptor alpha/beta Fibroblast growth factor receptor 1/2/3/4
Caspase-3 subunit p12/p20/p18 Neutrophil elastase Azurocidin (by homology) Myeloblastin (by homology)
Quinone oxidoreductase (by homology) Mitogen-activated protein kinase 8/9/10 (by homology) cGMP-specific 3',5'-cyclic phosphodiesterase Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (by homology)
Glucocorticoid receptor Mineralocorticoid receptor (by homology) 3-hydroxy-3-methylglutaryl-coenzyme A reductase  
Green: the same target as the original natural product; black: new target
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