Immunologically Active Compounds Library Probe+
Immunologically Active Compounds Library Probe+
Product Name Cat. No. Compounds Size (10 mM in Pre-dissolved in DMSO )
Immunologically Active Compounds Library Probe+ LA-008 Active Compounds 75
M series 131
C series 167
96-well plates
10 μL/well, 20 μL/well,  or 100 μL/well


  "Immunity" is an extremely important self-defense function of the human body. The human body can resist a huge variety of diseases by relying on its own immunity. Many active substances in natural products have immunological activity, such as polyphenols, flavonoids, and nitrogen-containing heterocyclic compounds.  
  The library collects 75 immune compounds and transforms them into potential new active molecules (~300 modified) by M+C series, which can be widely used in high-throughput screening (HTS) and high-content screening ( HCS), provides important clues for optimizing drug structure; at the same time, it continues to provide customized P series molecules.

Figure 1 Areas of known diseases related to immunologically Compounds





Table 2 Examples of known drug targets for immunologically Compounds



Xanthine dehydrogenase Carbonic anhydrase  Cytochrome P450 1B1/1A2/1A1/19A1 Arachidonate 5-lipoxygenase
Microtubule-associated protein tau Aldehyde dehydrogenase  Estrogen receptor alpha/beta Muscleblind-like protein 1/2/3
5-hydroxytryptamine receptor 1A/1B/2A/2B/2C (by homology) Beta amyloid A4 protein Tyrosyl-DNA phosphodiesterase 1 Androgen receptor 
cGMP-specific 3',5'-cyclic phosphodiesterase Glucocorticoid receptor  Epidermis-type lipoxygenase 3 (by homology) ATP-binding cassette sub-family G member 2
P-glycoprotein 1 Vascular endothelial growth factor receptor 1/2/3 (by homology) Platelet-derived growth factor receptor alpha/beta Adenosine receptor A1 (by homology)
Fibroblast growth factor receptor 1/2/3/4 Caspase-3 subunit p12 Caspase-7 subunit p20 (by homology) Caspase-6 subunit p18 (by homology)
Neutrophil elastase Azurocidin (by homology) Myeloblastin (by homology) Quinone oxidoreductase (by homology)
Mitogen-activated protein kinase 8/9/10 (by homology) Mineralocorticoid receptor (by homology) 3-hydroxy-3-methylglutaryl-coenzyme A reductase Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (by homology)
Arachidonate 15-lipoxygenase B      
Green: the same target as the original natural product; black: new target