Anti-Aging Active Compounds Library Probe+
Anti-Aging Active Compounds Library Probe+
Product Name Cat. No. Compounds Size (10 mM in Pre-dissolved in DMSO )
Anti-Aging Active Compounds Library Probe+ LA-009 Active Compounds 118 
M Series 230
C Series  274
96-well plates
10 μL/well, 20 μL/well,  or 100 μL/well

    Aging is a complex biological process. A variety of chronic diseases, such as cancer, diabetes, Alzheimer's disease, etc., can lead to aging-related problems such as the decline of tissue and organ function, structural degradation, reduction in adaptability and resistance.
    The library collects 118 anti-aging compounds, and transforms them into potential new active molecules through the M+C series (~600 have been transformed), which can be widely used in high-throughput screening (HTS) and high-content Screening (HCS) provides important clues for optimizing drug structure; at the same time, it continues to provide customized P series molecules.

Figure 1 Anti-aging active compounds known related disease fields

 

Table 2 Examples of known drug targets for anti-aging active compounds

Dopamine D2 receptor (by homology) Dopamine transporter (by homology) Carbonic anhydrase Alpha-(1,3)-fucosyltransferase 7
Squalene monooxygenase (by homology) ATP-binding cassette sub-family G member 2 NADPH oxidase 4 Plasminogen
Xanthine dehydrogenase Cytochrome P450 1B1 Cytochrome P450 19A1 Cytochrome P450 2C9
Cytochrome P450 3A4 Cytochrome P450 2C19 NADPH oxidase 4 Glucocorticoid receptor
Leukocyte elastase   Aldose reductase (by homology) Cyclooxygenase-2 Cyclooxygenase-1
Adenosine A3 receptor Adenosine A1 receptor (by homology) Transthyretin Arachidonate 5-lipoxygenase
Arachidonate 15-lipoxygenase Arachidonate 12-lipoxygenase Receptor-type tyrosine-protein phosphatase S Serotonin 1a (5-HT1a) receptor
Arachidonate 15-lipoxygenase Transthyretin Glucocorticoid receptor Insulin-like growth factor I receptor
Induced myeloid leukemia cell differentiation protein Mcl-1 Phosphodiesterase 5A Tyrosine-protein kinase receptor FLT3 Nitric oxide synthase, inducible (by homology)
Dual specificity mitogen-activated protein kinase kinase 1 Multidrug resistance-associated protein 1 P-glycoprotein 1 Aldehyde dehydrogenase
Estradiol 17-beta-dehydrogenase 2 Carbonyl reductase [NADPH] 1 Beta-secretase 1 Beta amyloid A4 protein
Induced myeloid leukemia cell differentiation protein Mcl-1 Delta opioid receptor Taste receptor type 2 member 31 Estrogen receptor alpha
Quinone reductase 2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Cannabinoid receptor 2 Melatonin receptor 1A
Melatonin receptor 1B      

 

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