Automated Chemoproteomics  

     The sample preparation process for chemoproteomics is complex and laborious. The process involves cell culture, drug treatment, cell lysis, click chemistry, magnetic bead enrichment, washing, enzymatic digestion, isotope labeling, desalting, among many other steps. Manual operations are not only time-consuming and labor-intensive but also prone to human error.

       Utilizing automated equipment can significantly enhance experimental efficiency, throughput, data accuracy, and data reproducibility.

       Our automated chemoproteomics sample preparation equipment is compatible to the preparation of most proteomics and chemoproteomics protocols. It is ideal for research institutions and pharmaceutical companies that have a high demand for repetitive sample preparation and large-scale data collection.

Application for Sample Preparation
LeadArt "Target Space Station"

     The "Target Space Station" developed by LeadArt is the first automated system for chemoproteomics sample preparation. The "Target Space Station" includes three modules, encompassing functions such as cell culture, probe/drug treatment, and proteome extraction. It is capable of efficiently preparing chemoproteomics samples, meeting the needs of high-throughput drug target screening and new drug discovery. 

     The "Target Space Station" enables us to significantly improve the quality and reproducibility of chemoproteomics data, reduce the cost and time of sample preparation, and accelerate the collection of chemical proteomics data. Currently, LeadArt is building the world's largest human protein targets-ligand bindings database in live cell.

 

Manual vs Automation

                                                                                         Note: Triplicate chemoproteomics data in Hela cells.