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Target Identification and Binding Site Recognition

Uncovering drug-target interactions is one of the key steps in modern drug discovery. LeadArt has the expertise in Photoaffinity Labeling–Affinity-Based Protein Profiling (PAL-AfBPP) and Activity-Based Protein Profiling (ABPP) technologies, offering services to identify targets and binding sites of active compounds.

Starting with active molecules identified from clinical findings or phenotypic screening (such as HTS, DEL, virtual screening, etc.), we employ chemoproteomics methods to qualitatively and quantitatively detect almost all protein-active molecule interactions in human live cells, revealing the mechanisms of action of active molecules. This process also yields information on protein-active molecule binding sites, while potentially identifying off-targets and targets of new indications.Utilizing the authentic wet lab data on protein-active molecule bindings, we can create more precise models of target-active compound interactions, which can then be used for efficient drug design and optimization.

Application for Target Identification

LeadArt PAL-AfBPP Process